Prognostic relevance of subclinical coronary and carotid atherosclerosis in a diabetic and non-diabetic asymptomatic population

Quale vantaggio, in termini di beneficio prognostico, con la valutazione eco carotidea e l'angio-TC in aggiunta alla valutazione clinica in una popolazione asintomatica? (Clin Cardiol 2018 Mar 3)

4 Aprile Apr 2018 6 months ago
  • Guglielmo M, Mushtaq S, Muscogiuri G, Andreini D, Pepi M, Pontone G

The aim of the study was to evaluate the incremental prognostic benefit of carotid artery disease and subclinical coronary artery disease (CAD) features in addition to clinical evaluation in a asymptomatic population.

Over a six-year period, 10-year-FRS together with carotid ultrasound (CUS) and coronary computed tomography angiography (CCTA) were evaluated for the prediction of major adverse cardiac events (MACE). The study enrolled a total of 517 consecutive asymptomatic patients,

The conclusions of the study show that, In an asymptomatic population, CAD and plaque positive remodeling increase the MACE prediction as compared to a model based on 10-year-FRS, carotid disease, and CACS estimation. In the subgroup of diabetic subjects, the percentage of segments with remodeled plaque is the only predictor of MACE.

Reference
1. Guaricci AI, Lorenzoni V, Guglielmo M, Mushtaq S, Muscogiuri G, Cademartiri F, Rabbat M, Andreini D, Serviddio G, Gaibazzi N, Pepi M, Pontone G. Prognostic relevance of subclinical coronary and carotid atherosclerosis in a diabetic and non-diabetic asymptomatic population. Clin Cardiol 2018 Mar 31. doi: 10.1002/clc.22952. [Epub ahead of print] Go to PubMed