The aim of the study was to evaluate the incremental prognostic benefit of carotid artery disease and subclinical coronary artery disease (CAD) features in addition to clinical evaluation in a asymptomatic population.
Over a six-year period, 10-year-FRS together with carotid ultrasound (CUS) and coronary computed tomography angiography (CCTA) were evaluated for the prediction of major adverse cardiac events (MACE). The study enrolled a total of 517 consecutive asymptomatic patients,
The conclusions of the study show that, In an asymptomatic population, CAD and plaque positive remodeling increase the MACE prediction as compared to a model based on 10-year-FRS, carotid disease, and CACS estimation. In the subgroup of diabetic subjects, the percentage of segments with remodeled plaque is the only predictor of MACE.