A reduced cardiac output (CO) response during exercise is a major limiting factor in heart failure (HF). Oxygen consumption (VO2) is directly proportional to CO. Peripheral mechanisms via arteriovenous oxygen difference (Δ(a-v)O2) play a pivotal role in chronic HF. We hypothesized a weak correlation between peak VO2 and peak CO with a greater Δ(a-v)O2 variability in most severe HF.
Del Torto A, Corrieri N, Vignati C, Gentile P, Cattadori G, Paolillo S, Agostoni P. Contribution of central and peripheral factors at peak exercise in heart failure patients with progressive severity of exercise limitation. Int J Cardiol 2017 Dec 1;248:252-256. doi: 10.1016/j.ijcard.2017.07.071