Mechanisms That Modulate Peripheral Oxygen Delivery during Exercise in Heart Failure

Annals of the American Thoracic Society

10 Luglio Lug 2017 4 months ago
  • Agostoni P

Oxygen uptake (V̇O2) measured at the mouth, which is equal to the cardiac output (C.O.) times the arterial-venous oxygen content difference [C(a-v)O2) ], increases over 10-20 fold in normal subjects during exercise. To achieve this substantial increase in oxygen uptake (V̇O2) = C.O. x C(a-v)O2) ) both cardiac output and arterial-venous difference must simultaneously increase. While this occurs in normal subjects, patients with heart failure cannot achieve significant increases in cardiac output and must rely primarily on changes in arterial-venous difference to increase V̇O2) during exercise. Inadequate oxygen delivery to the tissue during exercise in heart failure results in tissue anaerobiosis, lactic acid accumulation, and reduction in exercise tolerance. H+ is an important regulatory and feedback mechanism to facilitate additional oxygen delivery to the tissue (Bohr Effect) and further aerobic production of ATP when tissue anaerobic metabolism increases the production of lactate (anaerobic threshold). This H+ production in the muscle capillary promotes the continued unloading of oxygen (oxyhemoglobin desaturation) while maintaining the muscle capillary PO2 (Fick Principle) at a sufficient level to facilitate aerobic metabolism and overcome the diffusion barriers from capillary to mitochondria ("critical capillary PO2", 15 to 20 mm Hg). This mechanism is especially important during exercise in heart failure where cardiac output increase is severely constrained. Several compensatory mechanisms facilitate peripheral oxygen delivery during exercise in both normal persons and patients with heart failure.

Reference
Kisaka T, Stringer WW, Koike A, Agostoni P, Wasserman K. Mechanisms That Modulate Peripheral Oxygen Delivery during Exercise in Heart Failure. Ann Am Thorac Soc 2017 Jul 5. doi: 10.1513/AnnalsATS.201611-889FR. [Epub ahead of print]

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