Few data are available about safety of vitamin K antagonists (VKAs) in patients with clinical/demographic characteristics predisposing to an increased risk of bleeding.
The Authors of this study performed a meta-analysis to evaluate the safety of VKAs in patients with atrial fibrillation (AF) or venous thromboembolism (VTE) in the following subgroups of "high-risk" patients: elderly patients, patients with low body weight and patients with impaired renal function. The study included eleven randomized controlled trials for a total of 41,015 patients treated with VKAs (25,901 with AF and 15,114 with VTE).
Results of this meta-analysis suggest an increased risk of bleeding complications in "high-risk" patients. Although all results are significant, other studies focused on this issue are warranted to further validate these results.
- Di Minno MN, Ambrosino P, Dentali F. Safety of warfarin in "high-risk" populations: A meta-analysis of randomized and controlled trials. Thromb Res 2016 Dec 9 [Epub ahead of print] Go to PubMed