Association Between Haptoglobin Phenotype and Microvascular Obstruction in Patients With ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Study

La fenotipizzazione dell'aptoglobina può essere utilizzata per stratificare il rischio e valutare nuove terapie per ridurre il danno da riperfusione del miocardio in pazienti con STEMI? (JACC Cardiovasc Imaging 2018 Apr 13)

4 May May 2018 2 months ago
  • Pontone G, Andreini D, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Mushtaq S, Conte E, Cosentino N, Marenzi G, Bartorelli AL, Pepi M, Tremoli E, Banfi C.

Haptoglobin (Hp) is a plasma protein that prevents iron-mediated oxidative tissue damage. Since cardiac magnetic resonance (CMR) has emerged as the gold standard technique to detect left ventricular ejection fraction, extent of scar with late gadolinium enhancement technique, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment elevation myocardial infarction (STEMI), treated by primary percutaneous coronary intervention, this study aimed to evaluate the correlation between different haptoglobin phenotypes and myocardial infarction characteristics as detected by CMR in consecutive patients after STEMI.

According to the conclusions, Hp phenotype is an independent predictor of microvascular obstruction and could therefore be used for risk stratification and in assessing new therapies to reduce myocardial reperfusion injury in patients with STEMI.

Reference
1. Pontone G, Andreini D, Guaricci AI, Guglielmo M, Baggiano A, Muscogiuri G, Fusini L, Fazzari F, Berzovini C, Pasquini A, Mushtaq S, Conte E, Cosentino N, Rabbat MG, Marenzi G, Bartorelli AL, Pepi M, Tremoli E, Banfi C. Association Between Haptoglobin Phenotype and Microvascular Obstruction in Patients With ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Study. JACC Cardiovasc Imaging 2018 Apr 13. pii: S1936-878X(18)30276-6. doi: 10.1016/j.jcmg.2018.03.004. [Epub ahead of print] Go to PubMed