Physiological insights of exercise hyperventilation in arterial and chronic thromboembolic pulmonary hypertension

What about the causes of exercise hyperventilation in pulmonary hypertension patients? (Int J Cardiol 2018 May 15)

28 March Mar 2018 2 months ago
  • Farina S, Bruno N, Agalbato C, Contini M, Agostoni P

Pulmonary hypertension (PH) patients show, during exercise, an excessive increase in ventilation (VE) compared to carbon dioxide output (VCO2), determining a high VE/VCO2 slope. There are several possible causes, including an elevated dead space ventilation (VD), VE/perfusion (Q) mismatch and/or an enhanced peripheral or central chemoreceptor activity.

The Authors evaluated the causes of exercise hyperventilation in PH patients. According to the results, increased DS, VE/Q mismatch and chemorecptor response are among the main mechanisms involved in exercise hyperventilation in PH.

Reference
1. Farina S, Bruno N, Agalbato C, Contini M, Cassandro R, Elia D, Harari S, Agostoni P. Physiological insights of exercise hyperventilation in arterial and chronic thromboembolic pulmonary hypertension. Int J Cardiol 2018 May 15;259:178-182 Go to PubMed