Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats

Is platelet TF expression increased in a hypertensive status through a mechanism acting on megakaryocytes? And could that phenomenon be modulated by antihypertensive drugs? (Journal of Hypertension 2018 Feb 21)

1 March Mar 2018 4 months ago
  • Brambilla M, Gelosa P, Rossetti L, Castiglioni L, Zara C, Canzano P, Tremoli E, Sironi L, Camera M

Hypertension is a well known risk factor for thrombotic events such as myocardial infarction and stroke. Platelets express tissue factor (TF), the key activator of blood coagulation and thrombus formation.

The number of TF-positive platelets increases in pathological conditions characterized by thrombotic complications but whether this occurs in hypertension is unknown. In this study, the Authors investigated whether platelet TF expression is increased in a hypertensive status through a mechanism acting on megakaryocytes; the phenomenon could be modulated by antihypertensive drug as captopril; angiotensin (AngII) influences platelet TF expression.

In effect, according to the conclusions, the study shows for the first time that, in hypertension, the number of TF-positive megakaryocytes increases thus releasing in the circulation more platelets carrying a functionally active TF.

Reference

  • Brambilla M, Gelosa P, Rossetti L, Castiglioni L, Zara C, Canzano P, Tremoli E, Sironi L, Camera M. Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats. J Hypertens 2018 Feb 21. doi: 10.1097/HJH.0000000000001702. [Epub ahead of print] Go to PubMed