Excessive fluid therapy in patients with sepsis may be associated with risks that outweigh any benefit. In an observational cohort study (seven hundred and thirty ICUs in 84 countries), the Authors investigated the possible influence of early fluid balance on outcome in a large international database of ICU patients with sepsis.
In 1,808 patients with an admission diagnosis of sepsis, higher cumulative fluid balance at day 3 but (not in the first 24 hours) after ICU admission results independently associated with an increase in the hazard of death.
- Sakr Y, Rubatto Birri PN, Kotfis K, Nanchal R, Shah B, Kluge S, Schroeder ME, Marshall JC, Vincent JL; Intensive Care Over Nations Investigators. Sisillo E tra i collaboratori.
Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit. Crit Care Med 2017;45(3):386-394. Go to PubMed