A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines

Journal of Hypertension

26 April Apr 2017 7 months ago
  • Sironi L, Gelosa P

Uncoupling protein-2 (UCP2), a mitochondrial anion transporter involved in mitochondrial uncoupling, limiting reactive oxygen species formation, is significantly downregulated in kidneys of high-salt-fed stroke-prone spontaneously hypertensive rat (SHRSP), where it associates with increased renal damage occurrence.

Reference
Rubattu S, Cotugno M, Bianchi F, Sironi L, Gelosa P, Stanzione R, Forte M, De Sanctis C, Madonna M, Marchitti S, Pignieri A, Sciarretta S, Volpe M. A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines. J Hypertens 2017 Apr 10. doi: 10.1097/HJH.0000000000001374. [Epub ahead of print]

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