Prognostic role of beta-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database

European Journal of Heart Failulre

27 February Feb 2017 9 months ago
  • Mapelli M, Bonomi A, M, Veglia F, Salvioni E, Contini M, Apostolo A, Palermo P, Agostoni P

The use of β-blockers represents a milestone in the treatment of heart failure with reduced ejection fraction (HFrEF). Few studies have compared β-blockers in HFrEF, and there is little data on the effects of different doses.

The present study aimed to investigate in a large database of HFrEF patients (MECKI score database) the association of β-blocker treatment with a composite outcome of cardiovascular death, urgent heart transplantation or left ventricular assist device implantation, addressing the role of β-selectivity and dosage regimens.

Reference

  • Paolillo S, Mapelli M, Bonomi A, Corrà U, Piepoli M, Veglia F, Salvioni E, Gentile P, Lagioia R, Metra M, Limongelli G, Sinagra G, Cattadori G, Scardovi AB, Carubelli V, Scrutino D, Badagliacca R, Raimondo R, Emdin M, Magrì D, Correale M, Parati G, Caravita S, Spadafora E, Re F, Cicoira M, Frigerio M, Bussotti M, Minà C, Oliva F, Battaia E, Belardinelli R, Mezzani A, Pastormerlo L, Di Lenarda A, Passino C, Sciomer S, Iorio A, Zambon E, Guazzi M, Pacileo G, Ricci R, Contini M, Apostolo A, Palermo P, Clemenza F, Marchese G, Binno S, Lombardi C, Passantino A, Perrone Filardi P, Agostoni P. Prognostic role of β-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database. Eur J Heart Fail 2017 Feb 24 [Epub ahead of print] Go to PubMed