Rationale, design and goals of the HeartFlow assessing diagnostic value of non-invasive FFRCT in Coronary Care (ADVANCE) registry

Journal of Cardiovascular Computed Tomography

29 December Dec 2016 one month ago
  • Pontone G

Coronary CT angiography (CTA) is a reliable tool for the detection of coronary artery disease (CAD) that conveys significant prognostic information. It does not provide data on the hemodynamic significance of a given lesion, particularly in intermediate-grade stenosis. Fractional flow reserve by CT (FFRCT) can accurately predict the hemodynamic significance of coronary lesions.

The primary objective of the ADVANCE Registry – a multi-center, prospective registry designed to evaluate utility, clinical outcomes and resource utilization following FFRCT-guided treatment in clinically stable, symptomatic patients diagnosed with CAD by coronary CTA – is to determine whether the integration of FFRCT as an adjunct to coronary CTA will lead to a significant change in the management of CAD in patients with stable angina.

The primary endpoint of the Registry is the reclassification rate between the management plan based on coronary CTA alone versus CTA plus FFRCT. The secondary endpoints include the evaluation of the rate of invasive coronary angiography (ICA), revascularization, major adverse coronary events, resource utilization, cumulative radiation dose exposure and the rate of ICA without obstructive CAD at 3-year follow-up.

The ADVANCE registry is designed to assess the real-world impact of FFRCT on the clinical management of stable CAD when used along with coronary CTA.

Go to more informations about FFR-CT (in italian)


Reference

  • Chinnaiyan KM, Akasaka T, Amano T, Bax JJ, Blanke P, De Bruyne B, Kawasaki T, Leipsic J, Matsuo H, Morino Y, Nieman K, Norgaard BL, Patel MR, Pontone G, Rabbat M, Rogers C, Sand NP, Raff G. Rationale, design and goals of the HeartFlow assessing diagnostic value of non-invasive FFRCT in Coronary Care (ADVANCE) registry. J Cardiovasc Comput Tomogr 2016 Dec 14 [Epub ahead of print] Go to PubMed