In contrast to cardiomyocyte necrosis, which can be quantified by cardiac troponin (cTn), functional cardiomyocyte impairment, including mitochondrial dysfunction, has escaped clinical recognition in acute myocardial infarction (AMI) patients. Objective of this paper is to investigate the diagnostic accuracy for AMI and prognostic prediction of in-hospital mortality of cytochrome c, in two cohorts: a diagnostic cohort of patients presenting with suspected AMI, and a prognostic cohort of definite AMI patients.
At multivariable analysis, cytochrome c remained a significant independent predictor of in-hospital mortality, even after adjustment for major clinical confounders.
- Marenzi G, Cosentino N, Boeddinghaus J, Trinei M, Giorgio M, Milazzo V, Moltrasio M, Cardinale D, Sandri MT, Veglia F, Bonomi A, Kaech M, Twerenbold R, Nestelberger T, Reichlin T, Wildi K, Shrestha S, Kozhuharov N, Sabti Z, Cipolla CM, Mueller C, Bartorelli AL. Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction. Circ Res 2016 Oct 31 [Epub ahead of print] Go to PubMed