The New Frontier of Cardiac Computed Tomography Angiography: Fractional Flow Reserve and Stress Myocardial Perfusion

Current Treatment Options in Cardiovascular Medicine

2 November Nov 2016 4 months ago
  • Pontone G, Andreini D, Guglielmo M, Mushtaq S, Annoni A, Formenti A, Pepi M

OPINION STATEMENT

Several non-invasive functional imaging modalities are usually used as gatekeeper to invasive coronary angiography (ICA), but their diagnostic yield remains low with limited accuracy when compared to obstructive CAD at the time of ICA or invasive fractional flow reserve, FFR (still considered the gold standard for the evaluation of functionally relevant CAD).

More recently, the evaluation of FFR with CCTA (FFRCT) has demonstrated high diagnostic performance compared to invasive FFR. Additionally, stress myocardial computed tomography perfusion (CTP), that allow us to integrate the anatomical evaluation of coronary arteries with the functional relevance of coronary artery lesions.

In a new review, the Authors evaluate the technical aspects and clinical experience of FFRCT and stress-CTP in the evaluation of functionally relevant CAD discussing the strengths and weaknesses of each approach.


Reference

  1. Pontone G, Muscogiuri G, Andreini D, Guaricci AI, Guglielmo M, Mushtaq S, Baggiano A, Conte E, Beltrama V, Annoni A, Formenti A, Mancini E, Rabbat MG, Pepi M. The New Frontier of Cardiac Computed Tomography Angiography: Fractional Flow Reserve and Stress Myocardial Perfusion. Curr Treat Options Cardiovasc Med 2016;18(12):74. Go to PubMed