The concept of invasive fractional flow reserve (FFR) as a valid tool to detect the functional relevance of CAD was introduced in the early 1990s. Over the past few years, there has been a strong interest in computing FFR noninvasively by using coronary computed tomography angiography (CTA).
Beyond its strong diagnostic performance, the recent PLATFORM (Prospect Longitudinal Trial of FFRct: Outcome and Resource Impact) trial reported that a diagnostic strategy guided by FFR-CT safely cancelled 61% of ICA, reduced ICAs with no obstructive CAD by a dramatic 83%, improved quality of life for patients, and reduced healthcare costs.
In editorial comment, the Authors discuss a paper by Ko et al. that present an alternative technique for FFR-CT with boundary conditions derived from structural deformation of coronary lumen and aorta and reduced order or 1-dimensional fluid modelling.
- Pontone G, Rabbat MG. The New Era of Computational Fluid Dynamics in CT Angiography: Far Beyond the FFR Number. JACC Cardiovasc Imaging 2016 Oct 14. [Epub ahead of print] Go to Editorial