Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects are difficult to disentangle in patients with increased operative risk. A new study aimed to evaluate the incidence and prognostic impact of bleeding and transfusion of blood products in low-risk patients undergoing coronary artery bypass grafting (CABG).
Sixteen tertiary European centers of cardiac surgery contributed to the prospective European registry of CABG (E-CABG). The severity of bleeding was defined by the E-CABG bleeding severity classification and universal definition of perioperative bleeding (UDPB) classification.
Severe bleeding is rather uncommon in low-risk patients undergoing CABG, but it is associated with an increased risk of major adverse events. Prevention of excessive perioperative bleeding and patient blood management may improve the outcome of cardiac surgery also in low-risk patients.
- Kinnunen EM, De Feo M, Reichart D, Tauriainen T, Gatti G, Onorati F, Maschietto L, Bancone C, Fiorentino F, Chocron S, Bounader K, Dalén M, Svenarud P, Faggian G, Franzese I, Santarpino G, Fischlein T, Maselli D, Dominici C, Nardella S, Gherli R, Musumeci F, Rubino AS, Mignosa C, Mariscalco G, Serraino FG, Santini F, Salsano A, Nicolini F, Gherli T, Zanobini M, Saccocci M, Ruggieri VG, Philippe Verhoye J, Perrotti A, Biancari F. Incidence and prognostic impact of bleeding and transfusion after coronary surgery in low-risk patients. Transfusion 2016 Oct 17 [Epub ahead of print] Go to PubMed