“The senescence status of somatic stem/progenitor cells contributes to ageing process”, and “an individual is as old as old are its stem cells”. These quotes represent the concepts, which are actually object of investigations of researchers involved in ageing studies.
As life expectancy in Western countries continues to increase, so does the risk of experiencing comorbidity and disability in late life. The most effective means for reducing disease burden and control costs stays in delaying this progression, by extending “health-span”, i.e. the period of human life, during which one is generally healthy and free from serious diseases.
Accordingly, the effectiveness of stem/progenitor cell treatments, for delaying ageing process and age-related diseases, is an urgent need. We hope to see significant progresses in funding and support towards a comprehensive tool kit of rejuvenation therapies, currently not adequately supported. It is nonetheless encouraging to see the progresses reported in literature, as well as in papers in press in this journal.
The Editorial introduces a latest issue of Mechanisms of Ageing and Development, in wich a large range of current directions in research about this topic is described and discussed.
- Olivieri F, Pompilio G, Balistreri CR. Endothelial progenitor cells in ageing. Editorial. Mech Ageing Dev 2016 Sep 12 [Epub ahead of print] Go to PubMed (no abstract available)